Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation

被引:13
作者
Gatzonis, SD
Angelopoulos, EK
Daskalopoulou, EG
Mantouvalos, V
Chioni, A
Zournas, C
Siafakas, A
机构
[1] Athens Med Sch, Eginit Hosp, Dept Neurol, Athens 11528, Greece
[2] Athens Med Sch, Eginit Hosp, Dept Psychiat, Athens 11528, Greece
关键词
benzodiazepine; convulsive status epilepticus; flunitrazepam; lorazepam; seizures; side effects; withdrawal;
D O I
10.1016/S0376-8716(99)00059-9
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The misuse of benzodiazepines (BNZ)s may result in serious side effects. Three cases of convulsive status epilepticus (CSE) following abrupt discontinuation of long-term use of 25 mg of lorazepam in one patient and more than 20 mg of flunitrazepam in two patients are presented; they were non-epileptics and free of other high-risk factors for seizures. A favorable outcome for all three cases was noted. They remain free of seizures without antiepileptic treatment. Nevertheless, because of the extensive use of benzodiazepines, such rare high-risk side effects must be emphasized. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:95 / 97
页数:3
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