ATP and control of intracellular growth of mycobacteria by T cells

被引：28

作者：

Canaday, DH

Beigi, R

Silver, RF

Harding, CV

Boom, WH

Dubyak, GR

机构：

[1] Case Western Reserve Univ, Dept Physiol & Biophys, Cleveland, OH 44109 USA

[2] Univ Hosp Cleveland, Dept Med, Cleveland, OH 44106 USA

[3] Univ Hosp Cleveland, Dept Pathol, Cleveland, OH USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 11期

关键词：

D O I：

10.1128/IAI.70.11.6456-6459.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.

引用

收藏

页码：6456 / 6459

页数：4

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