Two selective novel triterpene glycosides from sea cucumber, Telenata ananas:: Inhibitors of chemokine receptor-5

被引：35

作者：

Hegde, VR

Chan, TM

Pu, HY

Gullo, VP

Patel, MG

Das, P

Wagner, N

Parameswaran, PS

Naik, CG

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

[2] Natl Inst Oceanog, Panaji, Goa, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(02)00599-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K-i) of 30 and 5 muM, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 muM, suggesting their selectivity for the CCR5 receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3203 / 3205

页数：3

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