Modified dideoxynucleosides: Synthesis of 2'-N-alkyl-3'-hydroxyalkyl-1',2'-isoxazolidinyl thymidine and 5-fluorouridine derivatives

被引：37

作者：

Chiacchio, U

Gumina, G

Rescifina, A

Romeo, R

Uccella, N

Casuscelli, F

Piperno, A

Romeo, G

机构：

[1] UNIV ARCAVACATA,DIPARTIMENTO CHIM,I-87036 ARCAVACATA,ITALY

[2] UNIV MESSINA,DIPARTIMENTO FARMACO CHIM,I-98168 MESSINA,ITALY

来源：

TETRAHEDRON | 1996年 / 52卷 / 26期

关键词：

D O I：

10.1016/0040-4020(96)00437-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazolidine nucleosides bearing an hydroxyl group at C-3, have been prepared in only three steps, with overall high yields. The synthetic approach is based on the 1,3-dipolar cycloaddition of 3-carboxyalkyl- or acylnitrones to vinyl acetate, followed by condensation with silylated thymine or 5-fluorouracil and NaBH4 reduction. (C) 1996 Elsevier Science Ltd

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页码：8889 / 8898

页数：10

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