Microbiota-mediated colonization resistance against intestinal pathogens

被引：1039

作者：

Buffie, Charlie G. ^{[1
]}

Pamer, Eric G. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; CLOSTRIDIUM-DIFFICILE INFECTION; INNATE LYMPHOID-CELLS; EXPERIMENTAL SALMONELLA INFECTION; INFLAMMATORY-BOWEL-DISEASE; LACTOBACILLUS-RHAMNOSUS GG; IN-VITRO INHIBITION; REGULATORY T-CELLS; ROR-GAMMA-T; DENDRITIC CELLS;

D O I：

10.1038/nri3535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and have effects on metabolic and immune pathways in their hosts. Recent studies indicate that the commensal microbiota can be manipulated to prevent and even to cure infections that are caused by pathogenic bacteria, particularly pathogens that are broadly resistant to antibiotics, such as vancomycin-resistant Enterococcus faecium, Gram-negative Enterobacteriaceae and Clostridium difficile. In this Review, we discuss how immune-mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota. We also review recent advances characterizing the ability of different commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts.

引用

页码：790 / 801

页数：12

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