Tegaserod-induced myocardial infarction: Case report and hypothesis

被引：57

作者：

Busti, AJ

Murillo, JR

Cryer, B

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Pharm Practice, Sch Pharm, Dallas, TX 75216 USA

[2] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX USA

[3] Univ Texas, Hlth Sci Ctr, San Antonio, TX 78285 USA

[4] Dallas Vet Affairs Med Ctr, Dallas, TX USA

[5] Univ Texas, SW Med Ctr, Dept Med, Dallas, TX USA

来源：

PHARMACOTHERAPY | 2004年 / 24卷 / 04期

关键词：

tegaserod; myocardial infarction; 5-HT; receptor agonist; migraine; triptans; cardiovascular adverse events; cardiovascular risk factors;

D O I：

10.1592/phco.24.5.526.33351

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Serotonin (5-hydroxytryptamine [5-HT])(1) receptor agonists, such as those used for treating migraine, can cause coronary artery contraction, coronary spasm, and even myocardial infarction. Tegaserod maleate is a relatively new 5-HT4 receptor agonist with moderate affinity for the 5-HT1 receptor. Currently, it is approved only for treatment of irritable bowel syndrome in women who have constipation as the primary symptom. However, it is also being administered as a promotility agent in patients with gastroparesis. Since tegaserod has affinity for the 5-HT1 receptor, it is plausible that tegaserod could cause the same types of cardiovascular adverse events seen with agents prescribed for management of migraine. We report the first case of a man who experienced a myocardial infarction after receiving only two 6-mg doses of tegaserod; we also provide a hypothesis regarding this event. When considering prescribing a drug with 5-HT1 receptor agonist activity, clinicians should review the patient's medical history specifically for the presence of underlying cardiovascular risk factors.

引用

页码：526 / 531

页数：6

共 40 条

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