Chiral Lewis acid-catalyzed enantioselective Michael reactions in water

被引：23

作者：

Kobayashi, S ^{[1
]}

Kakumoto, K

Mori, Y

Manabe, K

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, CREST, Tokyo, Japan

[2] JST, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2001年 / 41卷 / 04期

关键词：

D O I：

10.1092/6GRQ-YRVV-6KU3-RHGX

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric Michael reactions of beta-ketoesters with enones were effectively catalyzed by complexes of silver salts and BINAP derivatives in water. The reactions have proved to give Michael adducts in high yields with high enantioselectivities. These reactions are the first example of Lewis acid-catalyzed asymmetric Michael reactions in water.

引用

页码：247 / 249

页数：3

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