The role of interleukin-1 in seizures and epilepsy: A critical review

被引：87

作者：

Rijkers, K. ^{[1
,2
]}

Majoie, H. J. ^{[3
,4
]}

Hoogland, G. ^{[1
,2
]}

Kenis, G. ^{[2
]}

De Baets, M. ^{[2
]}

Vles, J. S. ^{[5
]}

机构：

[1] Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[3] Epilepsy Ctr Kempenhaeghe, Dept Neurol, Heeze, Netherlands

[4] Univ Med Ctr, Dept Neurol, Maastricht, Netherlands

[5] Univ Med Ctr, Dept Child Neurol, Maastricht, Netherlands

来源：

EXPERIMENTAL NEUROLOGY | 2009年 / 216卷 / 02期

关键词：

Epilepsy; Seizures; Interleukin-1; Review; TEMPORAL-LOBE EPILEPSY; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; MESSENGER-RNA LEVELS; FACTOR-KAPPA-B; IL-1 RECEPTOR ANTAGONIST; ACTIVATED PROTEIN-KINASE; INCREASED PLASMA-LEVELS; KAINIC ACID; FACTOR-ALPHA;

D O I：

10.1016/j.expneurol.2008.12.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Interleukin-1 (IL-1) has a multitude of functions in the central nervous system. Some of them involve mechanisms that are related to epileptogenesis. The role of IL-1 in seizures and epilepsy has been investigated in both patients and animal models. This review aims to synthesize, based on the currently available literature, the consensus role of IL-1 in epilepsy. Three lines of evidence suggest a role for IL-1: brain tissue from epilepsy patients and brain tissue from animal models shows increased IL-1 expression after seizures, and IL-1 has proconvulsive properties when applied excigeneously. However, opposing results have been published as well. More research is needed to fully establish the role of IL-1 in seizure generation and epilepsy, and to explore possible new treatment strategies that are based on interference with intracellular signaling cascades that are initiated when IL-1 binds to its receptor. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：258 / 271

页数：14

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