Antibody-mediated antigen sampling across intestinal epithelial barriers

被引:14
作者
Berin, M. Cecilia [1 ]
Li, Hongxing
Sperber, Kirk
机构
[1] Mt Sinai Sch Med, Dept Pediat, Jaffe Food Allergy Inst, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Clin Immunol & Immunobiol, New York, NY 10029 USA
来源
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS | 2006年 / 1072卷
关键词
antigen uptake; transcytosis; IgE; CD23;
D O I
10.1196/annals.1326.002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The epithelium of the gastrointestinal tract is the interface between luminal contents and the mucosal immune system. It must function as a selective barrier to limit penetration of antigens yet keep the mucosal immune system "informed" for the purpose of generating oral tolerance responses to food antigens or commensal organisms and host defense responses against pathogens. Alterations in epithelial barrier function have been proposed to play a significant role in gastrointestinal disease. In this review, we will discuss mechanisms of regulation of epithelial barrier function, and we will focus on the emerging understanding of how secreted immunoglobulins play a role in antigen-specific antigen sampling across the gastrointestinal epithelium.
引用
收藏
页码:253 / 261
页数:9
相关论文
共 39 条
  • [1] IGE LEVELS IN INTESTINAL JUICE
    BELUT, D
    MONERETVAUTRIN, DA
    NICOLAS, JP
    GRILLIAT, JP
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1980, 25 (05) : 323 - 332
  • [2] Role for IL-4 in macromolecular transport across human intestinal epithelium
    Berin, MC
    Yang, PC
    Ciok, L
    Waserman, S
    Perdue, MH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (05): : C1046 - C1052
  • [3] Rapid transepithelial antigen transport in rat jejunum: Impact of sensitization and the hypersensitivity reaction
    Berin, MC
    Kiliaan, AJ
    Yang, PC
    Groot, JA
    Taminiau, JAJM
    Perdue, MH
    [J]. GASTROENTEROLOGY, 1997, 113 (03) : 856 - 864
  • [4] Berin MC, 1998, J IMMUNOL, V161, P2561
  • [5] Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
    Berkes, J
    Viswanathan, VK
    Savkovic, SD
    Hecht, G
    [J]. GUT, 2003, 52 (03) : 439 - 451
  • [6] PINOCYTOSIS BY EPITHELIUM ASSOCIATED WITH LYMPHOID FOLLICLES IN BURSA OF FABRICIUS, APPENDIX, AND PEYERS PATCHES - ELECTRON-MICROSCOPIC STUDY
    BOCKMAN, DE
    COOPER, MD
    [J]. AMERICAN JOURNAL OF ANATOMY, 1973, 136 (04): : 455 - 477
  • [7] TRANSMISSION OF IMMUNITY FROM MOTHER TO YOUNG AND CATABOLISM OF IMMUNOGLOBULINS
    BRAMBELL, FW
    [J]. LANCET, 1966, 2 (7473) : 1087 - &
  • [8] Bacterial interactions with cells of the intestinal mucosa: toll-like receptors and NOD2
    Cario, E
    [J]. GUT, 2005, 54 (08) : 1182 - 1193
  • [9] Interferon γ induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process
    Clark, E
    Hoare, C
    Tanianis-Hughes, J
    Carlson, GL
    Warhurst, G
    [J]. GASTROENTEROLOGY, 2005, 128 (05) : 1258 - 1267
  • [10] CORNELL R, 1971, LAB INVEST, V25, P42