Combination of Methotrexate and Emodin Interacting with DNA

被引：12

作者：

Zhou, Hongbi ^{[1
]}

Shen, Qi ^{[1
]}

Zhang, Shusheng ^{[1
]}

Ye, Baoxian ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450001, Peoples R China

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Combination; DNA; electrochemical study; emodin; methotrexate; GLASSY-CARBON ELECTRODE; HERBAL DRUG EMODIN; ELECTROCHEMICAL-BEHAVIOR; CARCINOMA; APOPTOSIS; RESCUE; CELLS;

D O I：

10.1080/00032710902961057

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

The study on interaction of dsDNA with the combination of methotrexate and emodin demonstrated that emodin and methotrexate can form intermolecular hydrogen bonds that enhance the anticancer effect of methotrexate and decrease the side effects. The results show that a combination of synthetic and herbal medicines in treating cancer is very effective and can be used to select other effective combination uses of antitumor drugs. At the same time, according to different interaction models of methotrexate with dsDNA and ssDNA, methotrexate can be used to discriminate between dsDNA and ssDNA in a DNA biosensor as hybridization indicator.

引用

页码：1418 / 1429

页数：12

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