Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis

被引：42

作者：

Nelissen, I

Vandenbroeck, K

Fiten, P

Hillert, J

Olsson, T

Marrosu, MG

Opdenakker, G

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium

[2] Karolinska Inst, Huddinge Univ Hosp, Dept Clin Neurosci, Div Neurol, Stockholm, Sweden

[3] Karolinska Hosp, Ctr Mol Med, Neuroimmunol Unit, S-10401 Stockholm, Sweden

[4] Univ Cagliari, Dept Neurosci, Cagliari, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 105卷 / 01期

关键词：

gelatinase B; multiple sclerosis; microsatellite repeat; polymorphism; HLA stratification;

D O I：

10.1016/S0165-5728(00)00189-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human gelatinase B (MMP-9) gene promoter region contains a CA microsatellite repeat and a single nucleotide polymorphism which are known to influence transcriptional activity. These two polymorphisms were used to investigate the existence of an association between multiple sclerosis (MS) susceptibility and the MMP-9 gene. In a case-control analysis of 345 Swedish individuals and in a study of 125 Sardinian simplex families no genetic associations between the gelatinase B gene polymorphisms and MS susceptibility were found. These data reinforce the suggestion of epistasis in the regulation of the metalloproteinase-inhibitor balance in MS. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：58 / 63

页数：6

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