Reaction products of acetylcholinesterase and VX reveal a mobile histidine in the catalytic triad

被引：143

作者：

Millard, CB

Koellner, G

Ordentlich, A

Shafferman, A

Silman, I

Sussman, JL

机构：

[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[3] Israel Inst Biol Res, IL-70450 Ness Ziona, Israel

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 42期

关键词：

D O I：

10.1021/ja992704i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：9883 / 9884

页数：2

共 18 条

[1] N-15 NMR-SPECTROSCOPY OF HYDROGEN-BONDING INTERACTIONS IN THE ACTIVE-SITE OF SERINE PROTEASE - EVIDENCE FOR A MOVING HISTIDINE MECHANISM [J].

BACHOVCHIN, WW .

BIOCHEMISTRY, 1986, 25 (23) :7751-7759

[2] Probing the active site of acetylcholinesterase by molecular dynamics of its phosphonate ester adducts [J].

Bencsura, A ;

Enyedy, IY ;

Kovach, IM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (36) :8531-8541

[3] CRYSTAL-STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS [J].

BONE, R ;

SAMPSON, NS ;

BARTLETT, PA ;

AGARD, DA .

BIOCHEMISTRY, 1991, 30 (08) :2263-2272

[4] (HIS)C-EPSILON-H...O=C HYDROGEN-BOND IN THE ACTIVE-SITES OF SERINE HYDROLASES [J].

DEREWENDA, ZS ;

DEREWENDA, U ;

KOBOS, PM .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 241 (01) :83-93

[5] Catalytic triads and their relatives [J].

Dodson, G ;

Wlodawer, A .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (09) :347-352

[6] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[7] REFINED CRYSTAL-STRUCTURES OF AGED AND NON-AGED ORGANOPHOSPHORYL CONJUGATES OF GAMMA-CHYMOTRYPSIN [J].

HAREL, M ;

SU, CT ;

FROLOW, F ;

ASHANI, Y ;

SILMAN, I ;

SUSSMAN, JL .

JOURNAL OF MOLECULAR BIOLOGY, 1991, 221 (03) :909-918

[8] NEUTRON-DIFFRACTION IDENTIFIES HIS-57 AS THE CATALYTIC BASE IN TRYPSIN [J].

KOSSIAKOFF, AA ;

SPENCER, SA .

NATURE, 1980, 288 (5789) :414-416

[9] SERINE PROTEASES - STRUCTURE AND MECHANISM OF CATALYSIS [J].

KRAUT, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :331-358

[10]

MILLARD CB, 1999, J BIOCH, V38, P7032

← 1 2 →