Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils

被引：23

作者：

Li, L

Shen, YM

Yang, XS

Wu, WL

Wang, BG

Chen, ZH

Hao, XJ ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China

[2] Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China

来源：

BRAIN RESEARCH | 2002年 / 944卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Spiraea japonica var. acuta; Rosaceae; spiramine T; cerebral ischemia-reperfusion; antioxidant enzyme; nitric oxide synthase;

D O I：

10.1016/S0006-8993(02)02892-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. These results suggested that the neuroprotective effects of spiramine T were related to modulation of endogenous antioxidant enzymatic activities and reduction of the formation of nitric oxide. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：205 / 209

页数：5

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