Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy

被引：156

作者：

Chang, Yu-Hsun ^{[1
,2
]}

Wu, Kung-Chi ^{[3
]}

Harn, Horng-Jyh ^{[4
]}

Lin, Shinn-Zong ^{[5
]}

Ding, Dah-Ching ^{[2
,6
]}

机构：

[1] Buddhist Tzu Chi Gen Hosp, Dept Pediat, Hualien, Taiwan

[2] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan

[3] Buddhist Tzu Chi Gen Hosp, Dept Orthoped, Hualien, Taiwan

[4] Buddhist Tzu Chi Gen Hosp, Dept Pathol, Hualien, Taiwan

[5] Buddhist Tzu Chi Gen Hosp, Dept Neurosurg, Hualien, Taiwan

[6] Buddhist Tzu Chi Gen Hosp, Dept Obstet & Gynecol, 707 Chung Yang Rd,Sect 3, Hualien, Taiwan

来源：

CELL TRANSPLANTATION | 2018年 / 27卷 / 03期

关键词：

stroke; Parkinson's disease; osteoarthritis; mesenchymal stem cells; exosomes; miRNA; MESENCHYMAL STROMAL CELLS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MIDDLE CEREBRAL-ARTERY; TOTAL HIP-ARTHROPLASTY; HUMAN BONE-MARROW; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; EXTRACELLULAR VESICLES; ISCHEMIC-STROKE; PROMOTES NEUROPLASTICITY;

D O I：

10.1177/0963689717723636

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues. In addition, the paracrine effects of MSCs play crucial anti-inflammatory and immunosuppressive roles in immune cells. Extracellular vesicles (EVs) are vital mediators of cell-to-cell communication. Exosomes contain various molecules such as microRNA (miRNA), which mediates biological functions through gene regulation. Therefore, exosomes carrying miRNA or other molecules can enhance the therapeutic effects of MSC transplantation. MSC-derived exosomes have been investigated in various animal models representing stroke, PD, and OA. Exosomes are a subtype of EVs. This review article focuses on the mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects.

引用

页码：349 / 363

页数：15

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