Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: Radiation port scleroderma

Background: An association between systemic scleroderma, radiation, and breast cancer has been recognized. However, localized scleroderma in the radiation port of breast cancer patients has been rarely described. Objective: Our purpose was to describe the concurrence of localized scleroderma, supervoltage radiation, and breast carcinoma. Methods: Patients were prospectively evaluated in a tertiary care cancer center, and the Literature was reviewed. Results: We describe six patients with breast cancer in whom localized scleroderma developed within their radiation port. Conclusion: Radiation port localized scleroderma can be a sequela of supervoltage radiation therapy in patients with breast cancer. Recognition is important because localized scleroderma can clinically mimic recurrent breast carcinoma.