Prevalence of and risk factors for Clostridium difficile colonization at admission to an infectious diseases ward

被引:33
作者
Hutin, Y
Casin, I
Lesprit, P
Welker, Y
Decazes, JM
Lagrange, P
Modai, J
Molina, JM
机构
[1] HOP ST LOUIS,DEPT INFECT DIS,F-75010 PARIS,FRANCE
[2] HOP ST LOUIS,DEPT MICROBIOL,F-75010 PARIS,FRANCE
关键词
IMMUNODEFICIENCY-VIRUS INFECTION; HOSPITALIZED-PATIENTS; DIARRHEA; AIDS; COLITIS; ACQUISITION; RESIDENTS; ETIOLOGY;
D O I
10.1093/clinids/24.5.920
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A study of 240 consecutive admissions to a single hospital ward over a 6-month period was conducted to determine the prevalence of and risk factors for Clostridium difficile colonization at admission. The prevalence rate of C. difficile colonization at admission was 13.3%. Seventy-four percent of the patients admitted to the ward were infected with human immunodeficiency virus (HIV). Multivariate analysis identified three risk factors for C. difficile colonization: clindamycin use (adjusted odds ratio [OR], 9.4; P < .001), penicillin use (adjusted OR, 3.9; P = .018), and a history of cytomegalovirus infection (adjusted OR, 4.2; P = .02). C. difficile colonization at admission to our infectious diseases ward was common. Antibiotic treatments received before admission were the main risk factors for C. difficile colonization. HIV infection per se was not associated with C. difficile colonization. It is interesting that there was an association between C. difficile colonization and a history of cytomegalovirus infection.
引用
收藏
页码:920 / 924
页数:5
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