Distribution and roles of aquaporins in salivary glands

被引:132
作者
Delporte, Christine
Steinfeld, Serge
机构
[1] Univ Libre Bruxelles, Fac Med, Dept Biochem & Nutr, B-1070 Brussels, Belgium
[2] Erasme Univ Hosp, Dept Rheumatol, B-1070 Brussels, Belgium
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 08期
关键词
aquaporin; salivary gland; review;
D O I
10.1016/j.bbamem.2006.01.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Salivary glands are involved in secretion of saliva, which is known to participate in the protection and hydratation of mucosal structures within the oral cavity, oropharynx and oesophagus, the initiation of digestion, some antimicrobial defence, and the protection from chemical and mechanical stress. Saliva secretion is a watery fluid containing electrolytes and a mixture of proteins and can be stimulated by muscarinic and adrenergic agonists. Since water movement is involved in saliva secretion, the expression, localization and function of aquaporins (AQPs) have been studied in salivary glands. This review will focus on the expression, localization and functional roles of the AQPs identified in salivary glands. The presence of AQP1, AQP5 and AQP8 has been generally accepted by many, while the presence of AQP3, AQP4, AQP6 and AQP7 still remains controversial. Functionally, AQP5 seems to be the only AQP thus far to be clearly playing a major role in the salivary secretion process. Modifications in AQPs expression and/or distribution have been reported in xerostomic conditions. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:1061 / 1070
页数:10
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