Heck cross-coupling reaction of 3-iodoindazoles with methyl acrylate: a mild and flexible strategy to design 2-azatryptamines

被引：50

作者：

Collot, V ^{[1
]}

Varlet, D ^{[1
]}

Rault, S ^{[1
]}

机构：

[1] Ctr Etud & Rech Medicament Normandie, UFR Sci Pharmaceut, F-14032 Caen, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)00624-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to design 2-azabioisosteres of tryptamine, serotonin or melatonin, the conditions of the Heck coupling reaction of 3-iodoindazoles with methyl acrylate are studied. This reaction authorizes the synthesis of 3-indazolylpropenoates as key intermediates to prepare 3-indazolylpropionic acids and 3-indazolylethyl-amines. The flexible synthetic strategy allows molecular diversity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4363 / 4366

页数：4

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