MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer

被引：69

作者：

Chen, Wei-xian ^{[1
,2
]}

Zhong, Shan-liang ^{[3
]}

Ji, Ming-hua ^{[2
]}

Pan, Meng ^{[1
]}

Hu, Qing ^{[2
,4
]}

Lv, Meng-meng ^{[1
,2
]}

Luo, Zhou ^{[1
,2
]}

Zhao, Jian-hua ^{[3
]}

Tang, Jin-hai ^{[2
]}

机构：

[1] Nanjing Med Univ, Clin Sch 4, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Gen Surg, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Nanjing 210009, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Ctr Clin Lab, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Nanjing 210009, Jiangsu, Peoples R China

[4] Xuzhou Med Coll, Grad Sch, Xuzhou 221002, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Microvesicles; Exosomes; Drug resistance; Breast cancer; MicroRNAs; Extracellular vesicles; TUMOR-DERIVED MICROVESICLES; INTERCELLULAR COMMUNICATION; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; ENDOTHELIAL-CELLS; DRUG-RESISTANCE; DENDRITIC CELLS; MESSENGER-RNAS; STROMAL CELLS; STEM-CELLS;

D O I：

10.1007/s13277-013-1417-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Resistance to chemotherapy and endocrine therapy as well as targeted drugs is a major problem in treatment of breast cancer. Over the last decades, emerging studies have revealed that extracellular vesicles, which are chronically released by breast cancer cells and surrounding stromal cells, influence the action of most commonly used therapeutics. Such modulatory effects have been related to the transport of biologically active molecules including proteins and functional microRNAs. In this review, we highlight recent studies regarding extracellular vesicle-mediated microRNA delivery in formatting drug resistance. We also suggest the use of extracellular vesicles as a promising method in antiresistance treatment.

引用

收藏

页码：2883 / 2892

页数：10

相关论文

共 91 条

[1]

Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis [J].

Abusamra, AJ ;

Zhong, ZH ;

Zheng, XF ;

Li, M ;

Ichim, TE ;

Chin, JL ;

Min, WP .

BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) :169-173

[2]

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Kerbel, Robert S. ;

Allison, Anthony C. ;

Rak, Janusz .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3794-3799

[3]

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[4]

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells [J].

Antonyak, Marc A. ;

Li, Bo ;

Boroughs, Lindsey K. ;

Johnson, Jared L. ;

Druso, Joseph E. ;

Bryant, Kirsten L. ;

Holowka, David A. ;

Cerione, Richard A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :4852-4857

[5]

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes [J].

Ashiru, Omodele ;

Boutet, Philippe ;

Fernandez-Messina, Lola ;

Agueera-Gonzalez, Sonia ;

Skepper, Jeremy N. ;

Vales-Gomez, Mar ;

Reyburn, Hugh T. .

CANCER RESEARCH, 2010, 70 (02) :481-489

[6]

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches [J].

Baer, Caroline ;

Squadrito, Mario Leonardo ;

Iruela-Arispe, M. Luisa ;

De Palma, Michele .

EXPERIMENTAL CELL RESEARCH, 2013, 319 (11) :1626-1634

[7]

Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes [J].

Baj-Krzyworzeka, M ;

Szatanek, R ;

Weglarczyk, K ;

Baran, J ;

Urbanowicz, B ;

Branski, P ;

Ratajczak, MZ ;

Zembala, M .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2006, 55 (07) :808-818

[8]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[9]

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].

Bebawy, M. ;

Combes, V. ;

Lee, E. ;

Jaiswal, R. ;

Gong, J. ;

Bonhoure, A. ;

Grau, G. E. R. .

LEUKEMIA, 2009, 23 (09) :1643-1649

[10]

Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance [J].

Bergamaschi, A. ;

Katzenellenbogen, B. S. .

ONCOGENE, 2012, 31 (01) :39-47

← 1 2 3 4 5 6 7 8 9 10 →