Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

被引：57

作者：

Blink, E

Maianski, NA

Alnemri, ES

Zervos, AS

Roos, D

Kuijpers, TW

机构：

[1] CLB, Sanquin Res, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, NL-1066 CX Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, NL-1105 AZ Amsterdam, Netherlands

[4] Thomas Jefferson Univ, Kimmel Canc Inst, Ctr Apoptosis Res, Philadelphia, PA 19107 USA

[5] Univ Cent Florida, Dept Mol Biol & Microbiol, BSC, Orlando, FL 32816 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2004年 / 11卷 / 08期

关键词：

D O I：

10.1038/sj.cdd.4401409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：937 / 939

页数：3

共 10 条

[1] Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2
Cilenti, L
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Davis, H
Bonventre, JV
Alnemri, ES
Zervos, AS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) : 11489 - 11494
[2] Identification of Omi/HtrA-2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
Hegde, R
Srinivasula, SM
Zhang, ZJ
Wassell, R
Mukattash, R
Cilenti, L
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Zervos, AS
Fernandes-Alnemri, T
Alnemri, ES
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) : 432 - 438
[3] Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α-stimulated neutrophils
Liu, CY
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[J]. BLOOD, 2003, 101 (01) : 295 - 304
[4] Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis
Maianski, NA
Geissler, J
Srinivasula, SM
Alnemri, ES
Roos, D
Kuijpers, TW
[J]. CELL DEATH AND DIFFERENTIATION, 2004, 11 (02) : 143 - 153
[5] Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
Maianski, NA
Roos, D
Kuijpers, TW
[J]. BLOOD, 2003, 101 (05) : 1987 - 1995
[6] The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
Martins, LM
Iaccarino, I
Tenev, T
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Totty, NF
Lemoine, NR
Savopoulos, J
Gray, CW
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Dingwall, C
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[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) : 439 - 444
[7] Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
Srinivasula, SM
Gupta, S
Datta, P
Zhang, ZJ
Hegde, R
Cheong, NE
Fernandes-Alnemri, T
Alnemri, ES
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (34) : 31469 - 31472
[8] A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Suzuki, Y
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Nakayama, H
Takahashi, K
Takio, K
Takahashi, R
[J]. MOLECULAR CELL, 2001, 8 (03) : 613 - 621
[9] HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
Verhagen, AM
Silke, J
Ekert, PG
Pakusch, M
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Moritz, RL
Simpson, RJ
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[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) : 445 - 454
[10] Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis
Yang, QH
Church-Hajduk, R
Ren, JY
Newton, ML
Du, CY
[J]. GENES & DEVELOPMENT, 2003, 17 (12) : 1487 - 1496

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