Getting a grip on Thy-1 signaling

被引：51

作者：

Barker, Thomas H. ^{[2
]}

Hagood, James S. ^{[1
]}

机构：

[1] Univ Alabama, Birmingham, AL 35294 USA

[2] GA Tech Emory, Biomed Engn, Atlanta, GA 30332 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 05期

关键词：

Thy-1; Integrin; Neuron; Astrocyte; Context-dependent signaling; MICROVASCULAR ENDOTHELIAL-CELLS; NERVOUS-SYSTEM; ADHESION; FIBROBLASTS; EXPRESSION; MIGRATION; PROTEINS; BINDING; TRANSDUCTION; ASTROCYTES;

D O I：

10.1016/j.bbamcr.2008.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A recent study by Hermosilla et al. [T. Hermosilla, D. Munoz, R. Herrera-Molina, A. Valdivia, N. Munoz, S.U. Nham, P. Schneider, K. Burridge, A.F. Quest, L. Leyton, Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication, Biochim Biophys Acta 1783 (2008) 1111-1120] demonstrates that Thy-1 on neurons binds to alpha(v)beta(3) integrin on astrocytes via a conserved RLD motif, triggering the formation of focal adhesions and stress fibers via tyrosine phosphorylation and RhoA activation. This study adds to growing evidence regarding the signaling mechanisms and biological roles of Thy-1, an important regulator of context-dependent signaling. As knowledge of Thy-1 approaches its fiftieth year, it is critical to begin to synthesize insights from different fields to determine how this heretofore enigmatic molecule modulates cell behavior in both cis and trans. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：921 / 923

页数：3

共 23 条

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[2]

Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation [J].