Progressive multifocal leukoencephalopathy: simultaneous detection of JCV DNA and anti-JCV antibodies in the cerebrospinal fluid

被引:20
作者
Guillaume, B
Sindic, CJM
Weber, T
机构
[1] Catholic Univ Louvain, Lab Neurochim, B-1200 Brussels, Belgium
[2] Marien Hosp, Neurol Klin, D-22087 Hamburg, Germany
关键词
intrathecal immunity; JC virus; polymerase chain reaction; progressive multifocal; leukoencephalopathy;
D O I
10.1046/j.1468-1331.2000.00009.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We report on a case of biopsy-proven progressive multifocal leukoencephalopathy (PML) in a patient without obvious immunodeficiency. Analysis of the cerebrospinal fluid revealed the simultaneous presence of JC virus DNA and of locally produced, anti-JC virus antibodies. The intrathecal humoral immune response increased throughout the course of the disease, whereas the detection of the JC genome became ultimately negative in spite of the continuous extension of the lesions with fatal outcome.
引用
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页码:101 / 106
页数:6
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