A methyl glucuronate prodrug of phosphorodiamidic mustard

被引：10

作者：

Ghosh, AK

Farquhar, D

机构：

[1] Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10419-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-[Methyl(beta-D-glucopyranosyl)uronate]benzyl N,N,N',N'-tetrakis(2-chloroethyl) phosphorodiamidate, 3, was synthesized as a neutral prodrug of N,N,N',N'-tetrakis(2-chloroethyl) phosphorodiamidate mustard, 2c. In the presence of carboxylate esterase and beta-D-glucuronidase, 3 was converted to 2c and 4-hydroxybenzyl alcohol, 7. (C) 1997 Elsevier Science Ltd.

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页码：8795 / 8798

页数：4

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