Host range restriction and pathogenicity in the context of influenza pandemic

被引:224
作者
Neumann, Gabriele
Kawaoka, Yoshihiro [1 ]
机构
[1] Univ Wisconsin, Madison, WI 53706 USA
[2] Univ Tokyo, Tokyo 106, Japan
关键词
D O I
10.3201/eid1206.051336
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Influenza A viruses cause pandemics at random intervals. Pandemics are caused by viruses that contain a hemagglutinin (HA) surface glycoprotein to which human populations are immunologically naive. Such an HA can be introduced into the human population through reassortment between human and avian virus strains or through the direct transfer of an avian influenza virus to humans. The factors that determine the interspecies transmission and pathogenicity of influenza viruses are still poorly understood; however, the HA protein plays an important role in overcoming the interspecies barrier and in virulence in avian influenza viruses. Recently, the RNA polymerase (PB2) protein has also been recognized as a critical factor in host range restriction, while the nonstructural (NS1) protein affects the initial host immune responses. We summarize current knowledge of viral factors that determine host range restriction and pathogenicity of influenza A viruses.
引用
收藏
页码:881 / 886
页数:6
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