Amygdala BDNF signaling is required for consolidation but not encoding of extinction

被引：198

作者：

Chhatwal, Jasmeer P.

Stanek-Rattiner, Lisa

Davis, Michael

Ressler, Kerry J.

机构：

[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[2] Yerkes Res Ctr, Ctr Behav Neurosci, Atlanta, GA 30329 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 07期

关键词：

D O I：

10.1038/nn1718

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor ( BDNF) acting through the tyrosine kinase B receptor ( TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB ( TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB. t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.

引用

收藏

页码：870 / 872

页数：3

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