Biomarkers in acute respiratory distress syndrome

被引：81

作者：

Binnie, Alexandra ^{[1
]}

Tsang, Jennifer L. Y. ^{[2
]}

dos Santos, Claudia C. ^{[3
,4
,5
]}

机构：

[1] St Josephs Hlth Ctr, Dept Med, Toronto, ON, Canada

[2] McMaster Univ, Dept Crit Care Med, Hamilton, ON, Canada

[3] Univ Toronto, St Michaels Hosp, Keenan & Li Ka Shing Knowledge Inst, Toronto, ON M5B 1WB, Canada

[4] Univ Toronto, Inst Med Sci, Toronto, ON M5B 1WB, Canada

[5] Univ Toronto, Dept Med, Toronto, ON M5B 1WB, Canada

来源：

CURRENT OPINION IN CRITICAL CARE | 2014年 / 20卷 / 01期

关键词：

acute lung injury; acute respiratory distress syndrome; biomarkers; ventilator-induced; associated lung injury; ENDOTHELIAL GROWTH-FACTOR; ACUTE LUNG INJURY; PULMONARY-EDEMA FLUID; COMMUNITY-ACQUIRED PNEUMONIA; GLYCATION END-PRODUCTS; VON-WILLEBRAND-FACTOR; CLARA CELL PROTEIN; CRITICALLY-ILL; MECHANICAL VENTILATION; PLASMA ANGIOPOIETIN-2;

D O I：

10.1097/MCC.0000000000000048

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Purpose of reviewThe article provides an overview of efforts to identify and validate biomarkers in acute respiratory distress syndrome (ARDS) and a discussion of the challenges confronting researchers in this area.Recent findingsAlthough various putative biomarkers have been investigated in ARDS, the data have been largely disappointing and the troponin' of ARDS remains elusive. Establishing a relationship between measurable biological processes and clinical outcomes is vital to advancing clinical trials in ARDS and expanding our arsenal of treatments for this complex syndrome.SummaryThis article summarizes the current status of ARDS biomarker research and provides a framework for future investigation.

引用

页码：47 / 55

页数：9

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