Endoplasmic Reticulum Stress in Malignancy

被引：501

作者：

Clarke, Hanna J. ^{[1
]}

Chambers, Joseph E. ^{[1
]}

Liniker, Elizabeth ^{[1
]}

Marciniak, Stefan J. ^{[1
]}

机构：

[1] Univ Cambridge, CIMR, Dept Med, Cambridge CB2 0XY, England

来源：

CANCER CELL | 2014年 / 25卷 / 05期

关键词：

UNFOLDED PROTEIN RESPONSE; CANCER-CELL PROLIFERATION; TO-MESENCHYMAL TRANSITION; HUMAN TUMOR-CELLS; ER-STRESS; CALRETICULIN EXPOSURE; MULTIPLE-MYELOMA; BORTEZOMIB RESISTANCE; OXIDATIVE STRESS; POOR-PROGNOSIS;

D O I：

10.1016/j.ccr.2014.03.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

引用

页码：563 / 573

页数：11

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