Neuropathological studies of brain tissue in schizophrenia

被引:20
作者
Bunney, BG [1 ]
Potkin, SG [1 ]
Bunney, WE [1 ]
机构
[1] UNIV CALIF IRVINE,CALIF COLL MED,IRVINE,CA 92717
关键词
D O I
10.1016/S0022-3956(96)00038-6
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Postmortem neuropathological investigations in the last half decade provide increasing evidence compatible with a neurodevelopmental defect in schizophrenia. Basic and clinical data support hypotheses suggesting that disturbances in neurodevelopment in schizophrenia may involve the cortical subplate and a theorized second trimester ''window of vulnerability''. The Focus of this paper is on (I) selected methodological issues involved in the collection, analyses and preservation of human postmortem brain tissue; (2) a review of evidence showing morphological defects particularly in prefrontal cortical regions of the schizophrenic brain; and (3) potential future research directions. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:159 / 173
页数:15
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