Gene therapy of benign gynecological diseases

被引:25
作者
Hassan, Memy H. [2 ]
Othman, Essam E. [3 ]
Hornung, Daniela [4 ]
Al-Hendy, Ayman [1 ]
机构
[1] George Hubbard Hosp, Meharry Med Coll, Dept Obstet & Gynecol, Ctr Women Hlth Res, Nashville, TN 37208 USA
[2] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt
[3] Assiut Univ, Dept Obstet & Gynecol, Fac Med, Asyut, Egypt
[4] Univ Schleswig Holstein, Dept Obstet & Gynecol, Lubeck, Germany
关键词
Gene therapy; Adenovirus; Uterine leiomyoma; Endometriosis; UTERINE ARTERY EMBOLIZATION; ADENOVIRUS-MEDIATED DELIVERY; ESTROGEN-RECEPTOR GENE; THYMIDINE KINASE GENE; INHIBITS TUMOR-GROWTH; BREAST-CANCER; OVARIAN-CANCER; TRANSCRIPTION ACTIVATION; PROSTATE-CANCER; IN-VITRO;
D O I
10.1016/j.addr.2009.04.023
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes as potential molecular targets for gene therapy based approaches. Gene therapy strategies include: mutation compensation of dysregulated genes; replacement of defective tumor-suppressor genes; inactivation of oncogenes; introduction of suicide genes: immunogenic therapy and antiangiogenesis based approaches. Preclinical studies of gene therapy for various gynecological disorders have not only shown to be feasible, but also showed promising results in diseases such as uterine leiomyomas and endometriosis. In recent years, significant improvement in gene transfer technology has led to the development of targetable vectors, which have fewer side-effects without compromising their efficacy. This review provides an update on developing gene therapy approaches to treat common gynecological diseases such as uterine leiomyoma and endometriosis. (C) 2009 Published by Elsevier B.V.
引用
收藏
页码:822 / 835
页数:14
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