Magnetization transfer imaging to monitor the evolution of multiple sclerosis

被引:3
作者
Filippi, M [1 ]
机构
[1] Univ Milan, Osped San Raffaele, Inst Sci, Dept Neurosci,Neuroimaging Res Unit, I-20132 Milan, Italy
来源
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1999年 / 20卷 / 05期
关键词
D O I
10.1007/s100729970003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Magnetization transfer imaging (MTI) is a magnetic resonance imaging (MRT) technique that is now used in multiple sclerosis (MS) studies, and is thought to have a higher pathological specificity than conventional T2-weighted imaging. This review outlines the major contributions given by MTI for the understanding of MS evolution. MTI studies of individual MS lesions confirm the pathological heterogeneity of T2-weighted MRI abnormalities and the potential role of unenhanced T1-weighted hypointensities as specific markers of localized severe white matter disruption. Correlative cross-sectional and longitudinal studies using MTI and gadolinium (Gd)-enhanced MRI reveal that MTI findings may vary in lesions with different patterns of enhancement, and that MTI abnormalities are closely related to the onset and recovery of blood-brain barrier disruption in new MS plaques. MTI lesion load (LL) is highly correlated with T2-weighted MRI lesion load, but it has a limited reliability as a measure of MS lesion burden. On the other hand, measures obtained from MTI scans using whole-brain histogram analysis are highly correlated with the extent of MS abnormalities on conventional MRI scans, and predict patients' clinical disability well, since they are sensitive to both macro- and microscopic MS lesion burden in the whole brain and in specific regions. These data suggest that: (a) MTI is sensitive to different stages of lesion pathology and pathological evolution in MS patients; and (b) MT histogram analysis can provide a more global assessment of MS lesion burden, since it encompasses both macro- and microscopic MS pathology.
引用
收藏
页码:S232 / S240
页数:9
相关论文
共 78 条
[1]   PATHOLOGY OF MULTIPLE-SCLEROSIS - PROGRESSION OF LESION [J].
ADAMS, CWM .
BRITISH MEDICAL BULLETIN, 1977, 33 (01) :15-+
[2]   HISTOLOGICAL, HISTOCHEMICAL AND BIOCHEMICAL-STUDY OF THE MACROSCOPICALLY NORMAL WHITE MATTER IN MULTIPLE-SCLEROSIS [J].
ALLEN, IV ;
MCKEOWN, SR .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1979, 41 (01) :81-91
[3]   STUDIES ON PATHOGENESIS OF MULTIPLE-SCLEROSIS - PARTICIPATION OF LYSOSOMES ON DEMYELINATION IN CENTRAL NERVOUS-SYSTEM WHITE MATTER OUTSIDE PLAQUES [J].
ARSTILA, AU ;
RIEKKINEN, P ;
RINNE, UK ;
LAITINEN, L .
EUROPEAN NEUROLOGY, 1973, 9 (01) :1-20
[4]  
Bozzali M, 1999, AM J NEURORADIOL, V20, P1803
[5]   THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO [J].
BRENNER, RE ;
MUNRO, PMG ;
WILLIAMS, SCR ;
BELL, JD ;
BARKER, GJ ;
HAWKINS, CP ;
LANDON, DN ;
MCDONALD, WI .
MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (06) :737-745
[6]  
Campi A, 1996, NEURORADIOLOGY, V38, P115
[7]  
Campi A, 1996, INT J NEURORADIOL, V2, P134
[8]  
COMI G, 1999, IN PRESS J NEUROL SC
[9]   Early structural changes in acute MS lesions assessed by serial magnetization transfer studies [J].
Dousset, V ;
Gayou, A ;
Brochet, B ;
Caille, JM .
NEUROLOGY, 1998, 51 (04) :1150-1155
[10]  
Dousset V, 1997, AM J NEURORADIOL, V18, P895