Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats

被引：81

作者：

Kumar, G ^{[1
]}

Banu, GS ^{[1
]}

Pappa, PV ^{[1
]}

Sundararajan, M ^{[1
]}

Pandian, MR ^{[1
]}

机构：

[1] Muthayammal Coll Arts & Sci, Ctr Biotechnol, Namakkal 637408, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 92卷 / 01期

关键词：

paracetamol; thioacetamide; hepatic damage; serum enzymes; hepatoprotection;

D O I：

10.1016/j.jep.2003.12.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The ethanolic extract of Trianthema portulacastrum L. (Aizoaceae) showed a significant dose dependent (100mg, 200mg/kg p.o. 10x) protective effect against paracetamol and thioacetamide induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin (BRN), and total protein (TP). The plant extract completely prevented the toxic effects of paracetamol (acetaminophen) and thioacetamide on the above serum parameters. A significant hepatoprotective activity of the ethanolic extracts of Trianthema portulacastrum L. was reported. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：37 / 40

页数：4

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