Active defense under oxidative stress. The antioxidant responsive element

被引：132

作者：

Lyakhovich, V. V.

Vavilin, V. A.

Zenkov, N. K.

Menshchikova, E. B.

机构：

[1] Russian Acad Med Sci, Siberian Branch, Inst Mol Biol & Biophys, Novosibirsk 630117, Russia

[2] Russian Acad Med Sci, Siberian Branch, Sci Ctr Clin & Expt Med, Novosibirsk 630117, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2006年 / 71卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

oxidative stress; antioxidant responsive element;

D O I：

10.1134/S0006297906090033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is important for cell defense under conditions of oxidative stress and also for detoxification of electrophilic xenobiotics. There are differences in regulation of intracellular homeostasis involving Nrf2-mediated activation of ARE and other redox-sensitive factors (NF-kappa B and AP-1).

引用

收藏

页码：962 / 974

页数：13

相关论文

共 118 条

[1]

Alam J, 2000, J BIOL CHEM, V275, P27694

[2]

Regulation of metallothionein gene expression by oxidative stress and metal ions [J].

Andrews, GK .

BIOCHEMICAL PHARMACOLOGY, 2000, 59 (01) :95-104

[3]

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases [J].

Awasthi, YC ;

Yang, YS ;

Tiwari, NK ;

Patrick, B ;

Sharma, A ;

Li, J ;

Awasthi, S .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (05) :607-619

[4]

Bach FH, 2002, WIEN KLIN WOCHENSCHR, V114, P1

[5]

Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element [J].

Balogun, E ;

Hoque, M ;

Gong, PF ;

Killeen, E ;

Green, CJ ;

Foresti, R ;

Alam, J ;

Motterlini, R .

BIOCHEMICAL JOURNAL, 2003, 371 :887-895

[6]

The GI-GPx gene is a target for Nrf2 [J].

Banning, A ;

Deubel, S ;

Kluth, D ;

Zhou, ZW ;

Brigelius-Flohé, R .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (12) :4914-4923

[7]

Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements [J].

Bea, F ;

Hudson, FN ;

Chait, A ;

Kavanagh, TJ ;

Rosenfeld, ME .

CIRCULATION RESEARCH, 2003, 92 (04) :386-393

[8]

Ben-Dor A, 2005, MOL CANCER THER, V4, P177

[9]

Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc [J].

Bi, YY ;

Palmiter, RD ;

Wood, KM ;

Ma, Q .

BIOCHEMICAL JOURNAL, 2004, 380 :695-703

[10]

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression [J].

Bloom, DA ;

Jaiswal, AK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :44675-44682

← 1 2 3 4 5 6 7 8 9 10 →