Determinants of atrial fibrillation development in patients with hypertrophic cardiomyopathy

被引：101

作者：

Losi, MA ^{[1
]}

Betocchi, S ^{[1
]}

Aversa, M ^{[1
]}

Lombardi, R ^{[1
]}

Miranda, M ^{[1
]}

D'Alessandro, G ^{[1
]}

Cacace, A ^{[1
]}

Tocchetti, CG ^{[1
]}

Barbati, G ^{[1
]}

Chiariello, M ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med, Sch Med, I-80131 Naples, Italy

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 94卷 / 07期

关键词：

D O I：

10.1016/j.amjcard.2004.06.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Predictors of the development of atrial fibrillation (AF) in patients who have hypertrophic cardiomyopathy (HC) have not been extensively studied, although, in these patients, AF contributes to the exacerbation of symptoms and the development of heart failure. The present study determined the role of left atrial (LA) function in the development of AF in patients who have HC. One hundred fifty consecutive patients who had HC, had no history of AF, and who were followed for 5.2 +/- 2.9 years constituted the study population. Using M-mode echocardiography, we measured LA function as global LA fractional shortening and LA diameter. LA volume was measured from 2-dimensional 4-chamber views by the method of disks. During follow-up, 20 patients developed AF. LA function was an independent predictor of AF (odds ratio 0.716, p = <0.001), whereas LA diameter and volume were predictors in addition to age. Kaplan-Meier analysis showed that LA dysfunction carried a high risk of AF. Thus, in patients who have HC, LA function is a strong predictor of AF development and is independent of age. (C) 2004 by Excerpta Medica, Inc.

引用

页码：895 / 900

页数：6

共 27 条

[1] ESTIMATION OF LEFT-VENTRICULAR FILLING PRESSURES USING 2-DIMENSIONAL AND DOPPLER-ECHOCARDIOGRAPHY IN ADULT PATIENTS WITH CARDIAC DISEASE - ADDITIONAL VALUE OF ANALYZING LEFT ATRIAL SIZE, LEFT ATRIAL EJECTION FRACTION AND THE DIFFERENCE IN DURATION OF PULMONARY VENOUS AND MITRAL FLOW VELOCITY AT ATRIAL CONTRACTION [J].