A motif for quinone binding sites in respiratory and photosynthetic systems

被引:148
作者
Fisher, N [1 ]
Rich, PR [1 ]
机构
[1] UCL, Glynn Lab Bioenerget, Dept Biol, London WC1E 6BT, England
基金
英国惠康基金;
关键词
quinone binding site; photosystems; protein motif; dehydrogenases; homology;
D O I
10.1006/jmbi.2000.3509
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many of the membrane-bound protein complexes of respiratory and photosynthetic systems are reactive with quinones. To date, no clear structural relationship between sites that bind quinone has been defined, apart from that in the homologous family of "type II" photosynthetic reaction centres. We show here that a structural element containing a weak sequence motif is common to the Q(A) and Q(B) sites of bacterial reaction centres and the Q(i) site of the mitochondrial bc(1) complex. Analyses of sequence databases indicate that this element may also be present in the PsaA/B subunits of photosystem I, in the ND4 and ND5 subunits of complex I and, possibly, in the mitochondrial alternative quinol oxidase. This represents a first step in the structural classification of quinone binding sites. (C) 2000 Academic Press.
引用
收藏
页码:1153 / 1162
页数:10
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