The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy

被引：192

作者：

Lee, P. H. ^{[1
]}

Lee, G. ^{[1
]}

Park, H. J. ^{[1
]}

Bang, O. Y. ^{[1
]}

Joo, I. S. ^{[1
]}

Huh, K. ^{[1
]}

机构：

[1] Ajou Univ, Sch Med, Coll Med, Brain Dis Res Ctr,Dept Neurol, Suwon 442749, Kyungki, South Korea

来源：

JOURNAL OF NEURAL TRANSMISSION | 2006年 / 113卷 / 10期

关键词：

alpha-synuclein; Parkinson's disease; multiple system atrophy;

D O I：

10.1007/s00702-005-0427-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

alpha-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma alpha-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The alpha-synuclein level was significantly elevated in patients with PD (79.9 +/- 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 +/- 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 +/- 3.9 pg/ml). The alpha-synuclein level was higher in patients with PD than in those with MSA (79.9 +/- 4.0 vs 78.1 +/- 3.5, p = 0.016). Our study demonstrated that the alpha-synuclein level in plasma is elevated in patients with PD and MSA.

引用

页码：1435 / 1439

页数：5

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