Calcium channelopathies

被引：27

作者：

Lorenzon, NM ^{[1
]}

Beam, KG ^{[1
]}

机构：

[1] Colorado State Univ, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA

来源：

KIDNEY INTERNATIONAL | 2000年 / 57卷 / 03期

关键词：

calcium channel; gene mutation; cellular function; voltage-gated Ca channels; muscle; neuron;

D O I：

10.1046/j.1523-1755.2000.00917.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system. This article reviews calcium channelopathies in humans and mice.

引用

页码：794 / 802

页数：9

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