TAP off - Tumors on

被引：199

作者：

Seliger, B

Maeurer, MJ

Ferrone, S

机构：

[1] UNIV MAINZ, DEPT MED MICROBIOL, D-55131 MAINZ, GERMANY

[2] NEW YORK MED COLL, DEPT MICROBIOL & IMMUNOL, VALHALLA, NY 10595 USA

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(97)01052-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.

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页码：292 / 299

页数：8

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