Pharmacodynamics of cefepime in patients with Gram-negative infections

被引：219

作者：

Tam, VH

McKinnon, PS

Akins, RL

Rybak, MJ

Drusano, GL

机构：

[1] Albany Med Coll, Clin Res Inst, Div Clin Pharmacol, Albany, NY 12208 USA

[2] Wayne State Univ, Sch Med, Detroit, MI USA

[3] Detroit Receiving Hosp & Univ Hlth Ctr, Dept Pharm Serv, Antiinfect Res Lab, Detroit, MI USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 03期

关键词：

D O I：

10.1093/jac/dkf130

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We conducted a prospective, open-label study to delineate a relationship between exposure and outcomes in 36 patients treated with cefepime. Twenty patients had documented Gram-negative infections. Timed blood and urine samples were obtained at steady state to determine pharmacokinetic and pharmacodynamic parameters. Microbiological success was significantly correlated with the proportion of the dosing interval that cefepime concentrations exceeded 4.3 x MIC. Our results support in vitro data that suggest bactericidal activity of beta-lactams is optimized at concentrations similar to4 x MIC. These results should be validated by large prospective clinical trials.

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页码：425 / 428

页数：4

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