Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy

被引：42

作者：

Attilakos, Achilleas

Papakonstantinou, Evangellos

Schulpis, Kleopatra

Voudris, Konstantinos

Katsarou, Eustathia

Mastroyianni, Sotiria

Garoufi, Anastasia

机构：

[1] Univ Athens Panagiotis & Aglaia Kyriakou, Dept Pediat 2, Childrens Hosp, Athens 15125, Greece

[2] Aghia Sophia Childrens Hosp, Inst Child Hlth, Athens, Greece

[3] Panagiotis & Aglaia Kyriakou Childrens Hosp, Dept Neurol, Athens, Greece

来源：

EPILEPSY RESEARCH | 2006年 / 71卷 / 2-3期

关键词：

homocysteine; epilepsy; sodium valproate; carbamazepine; monotherapy; children;

D O I：

10.1016/j.eplepsyres.2006.06.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n = 32) and carbamazepine (group B, n = 20) monotherapy. P-tHcy significantly increased in both groups, s-F and s-B12 significantly increased in group A, while s-F and p-PLP significantly decreased in group B. Our study showed an early effect of antiepileptic drug treatment on homocysteine metabolism. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：229 / 232

页数：4

共 16 条

[1]

Antiepileptic drugs as independent predictors of plasma total homocysteine levels [J].