Serial Susceptibility Weighted MRI Measures Brain Iron and Microbleeds in Dementia

被引：116

作者：

Kirsch, Wolff ^{[1
]}

McAuley, Grant ^{[1
]}

Holshouser, Barbara ^{[2
]}

Petersen, Floyd ^{[3
]}

Ayaz, Muhammad ^{[4
]}

Vinters, Harry V. ^{[5
]}

Dickson, Cindy ^{[1
]}

Haacke, E. Mark ^{[4
]}

Britt, William, III ^{[6
]}

Larsen, James ^{[7
]}

Kim, Ivan ^{[1
]}

Mueller, Claudius ^{[1
]}

Schrag, Matthew ^{[1
]}

Kido, Daniel ^{[2
]}

机构：

[1] Loma Linda Univ, Neurosurg Ctr Res Training & Educ, Loma Linda, CA 92350 USA

[2] Loma Linda Univ, Med Ctr, Dept Radiol, Loma Linda, CA 92350 USA

[3] Loma Linda Univ, Hlth Res Consulting Grp, Loma Linda, CA 92350 USA

[4] MRI Inst Biomed Res, Detroit, MI USA

[5] Univ Calif Los Angeles, Med Ctr, Div Neuropathol, Los Angeles, CA 90024 USA

[6] Loma Linda Univ, Dept Psychiat, Loma Linda, CA 92350 USA

[7] Loma Linda Univ Hlth Care, Dept Med, Loma Linda, CA USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 17卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Amyloid angiopathy; brain; cognitive impairment; dementia; globus pallidal iron; microbleeds; putaminal iron; susceptibility weighted imaging; CEREBRAL AMYLOID ANGIOPATHY; MILD COGNITIVE IMPAIRMENT; EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; DIFFUSE AXONAL INJURY; DEEP GRAY-MATTER; ALZHEIMER-DISEASE; PUTAMEN NUCLEI; BASAL GANGLIA; ACCUMULATION; CHILDREN;

D O I：

10.3233/JAD-2009-1073

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new iron sensitive MR sequence ( susceptibility weighted imaging-SWI) enabling the simultaneous quantitation of regional brain iron levels and brain microbleeds (BMB) has been acquired serially to study dementia. Cohorts of mildly cognitively impaired (MCI) elderly (n = 73) and cognitively normal participants ( n = 33) have been serially evaluated for up to 50 months. SWI phase values ( putative iron levels) in 14 brain regions were measured and the number of BMB were counted for each SWI study. SWI phase values showed a left putaminal mean increase of iron ( decrease of phase values) over the study duration in 27 participants who progressed to dementia compared to Normals ( p = 0.035) and stable MCI ( p = 0.01). BMB were detected in 9 out of 26 (38%) MCI participants who progressed to dementia and are a significant risk factor for cognitive failure in MCI participants [ risk ratio = 2.06 (95% confidence interval 1.37-3.12)]. SWI is useful to measure regional iron changes and presence of BMB, both of which may be important MR-based biomarkers for neurodegenerative diseases.

引用

页码：599 / 609

页数：11

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