Facile purification of honokiol and its antiviral and cytotoxic properties

被引:51
作者
Amblard, Franck
Delinsky, David
Arbiser, Jack L.
Schinazi, Raymond F. [1 ]
机构
[1] Emory Univ, Sch Med, Dept Pediat & Dermatol, Atlanta, GA 30322 USA
[2] Vet Affairs Med Ctr, Decatur, GA 30033 USA
关键词
D O I
10.1021/jm060268m
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A separation of honokiol 1 from the closely structurally related magnolol 2 was developed. Honokiol demonstrated weak activity against HIV-1 in human lymphocytes.
引用
收藏
页码:3426 / 3427
页数:2
相关论文
共 12 条
[1]   Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo [J].
Bai, XH ;
Cerimele, F ;
Ushio-Fukai, M ;
Waqas, M ;
Campbell, PM ;
Govindarajan, B ;
Der, CJ ;
Battle, T ;
Frank, DA ;
Ye, KQ ;
Murad, E ;
Dubiel, W ;
Soff, G ;
Arbiser, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) :35501-35507
[2]   Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan [J].
Esumi, T ;
Makado, G ;
Zhai, HF ;
Shimizu, Y ;
Mitsumoto, Y ;
Fukuyama, Y .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) :2621-2625
[3]   Enantioselective syntheses of (S)- and (R)-8,9-dihydroxydihydromagnolol [J].
Gu, WX ;
She, XG ;
Pan, XF ;
Yang, TK .
TETRAHEDRON-ASYMMETRY, 1998, 9 (08) :1377-1380
[4]  
LO YC, 1994, BIOCHEM PHARMACOL, V47, P549, DOI 10.1016/0006-2952(94)90187-2
[5]   Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice [J].
Nakazawa, T ;
Yasuda, T ;
Ohsawa, K .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (11) :1583-1591
[6]   ACTIVITIES OF 3'-AZIDO-3'-DEOXYTHYMIDINE NUCLEOTIDE DIMERS IN PRIMARY LYMPHOCYTES INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
SCHINAZI, RF ;
SOMMADOSSI, JP ;
SAALMANN, V ;
CANNON, DL ;
XIE, MY ;
HART, GC ;
SMITH, GA ;
HAHN, EF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (06) :1061-1067
[7]   Separation procedures applicable to lignan analysis [J].
Slanina, J ;
Glatz, Z .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 812 (1-2) :215-229
[8]   Antiviral activities and cellular toxicities of modified 2′,3′-dideoxy-2′,3′-didehydrocytidine analogues [J].
Stuyver, LJ ;
Lostia, S ;
Adams, M ;
Mathew, JS ;
Pai, BS ;
Grier, J ;
Tharnish, PM ;
Choi, Y ;
Chong, Y ;
Choo, H ;
Chu, CK ;
Otto, MJ ;
Schinazi, RF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) :3854-3860
[9]  
TAKEYA T, 1986, CHEM PHARM BULL, V34, P2066
[10]   EDRF-RELEASE AND CA++-CHANNEL BLOCKADE BY MAGNOLOL, AN ANTIPLATELET AGENT ISOLATED FROM CHINESE HERB MAGNOLIA-OFFICINALIS, IN RAT THORACIC AORTA [J].
TENG, CM ;
YU, SM ;
CHEN, CC ;
HUANG, YL ;
HUANG, TF .
LIFE SCIENCES, 1990, 47 (13) :1153-1161