The nonlipid effects of statins on endothelial function

被引：51

作者：

Beckman, Joshua A. ^{[1
]}

Creager, Mark A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.tcm.2006.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.

引用

页码：156 / 162

页数：7

共 89 条

[1] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study
Albert, MA
Danielson, E
Rifai, N
Ridker, PM
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01): : 64 - 70
[2] Prior statin therapy is associated with a decreased rate of severe sepsis
Almog, Y
Shefer, A
Novack, V
Maimon, N
Barski, L
Eizinger, M
Friger, M
Zeller, L
Danon, A
[J]. CIRCULATION, 2004, 110 (07) : 880 - 885
[3] CLOSE RELATION OF ENDOTHELIAL FUNCTION IN THE HUMAN CORONARY AND PERIPHERAL CIRCULATIONS
ANDERSON, TJ
UEHATA, A
GERHARD, MD
MEREDITH, IT
KNAB, S
DELAGRANGE, D
LIEBERMAN, EH
GANZ, P
CREAGER, MA
YEUNG, AC
SELWYN, AP
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (05) : 1235 - 1241
[4] THE EFFECT OF CHOLESTEROL-LOWERING AND ANTIOXIDANT THERAPY ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION
ANDERSON, TJ
MEREDITH, IT
YEUNG, AC
FREI, B
SELWYN, AP
GANZ, P
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (08) : 488 - 493
[5] Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
Baigent, C
Keech, A
Kearney, PM
Blackwell, L
Buck, G
Pollicino, C
Kirby, A
Sourjina, T
Peto, R
Collins, R
Simes, J
[J]. LANCET, 2005, 366 (9493) : 1267 - 1278
[6] Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein
Beckman, JA
Liao, JK
Hurley, S
Garrett, LA
Chui, DS
Mitra, D
Creager, MA
[J]. CIRCULATION RESEARCH, 2004, 95 (02) : 217 - 223
[7] Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
Beckman, JA
Goldfine, AB
Gordon, MB
Garrett, LA
Keaney, JF
Creager, MA
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (06): : H2392 - H2398
[8] Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins
Brouet, A
Sonveaux, P
Dessy, C
Moniotte, S
Balligand, JL
Feron, O
[J]. CIRCULATION RESEARCH, 2001, 89 (10) : 866 - 873
[9] PROTEIN LIPIDATION IN CELL SIGNALING
CASEY, PJ
[J]. SCIENCE, 1995, 268 (5208) : 221 - 225
[10] Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes
Cheung, BMY
Lauder, IJ
Lau, CP
Kumana, CR
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2004, 57 (05) : 640 - 651

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