The dynamic life of natural killer cells

被引:427
作者
Yokoyama, WM [1 ]
Kim, SJ
French, AR
机构
[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Div Rheumatol,Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Howard Hughes Med Inst, Div Rheumatol,Dept Pathol & Immunol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
关键词
NK cells; development; proliferation; virus; innate immunity;
D O I
10.1146/annurev.immunol.22.012703.104711
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) cells play important roles in immunological processes, including early defense against viral infections. This review provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature peripheral responses and their ultimate demise, with particular emphasis on mouse NK cells and viral infections.
引用
收藏
页码:405 / 429
页数:25
相关论文
共 179 条
[81]   NK cell receptors [J].
Lanier, LL .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :359-393
[82]   Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice [J].
Lee, SH ;
Zafer, A ;
de Repentigny, Y ;
Kothary, R ;
Tremblay, ML ;
Gros, P ;
Duplay, P ;
Webb, JR ;
Vidal, SM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :515-526
[83]  
Lee SH, 2001, NAT GENET, V28, P42, DOI 10.1038/88247
[84]   Murine natural killer cell progenitors and their requirements for development [J].
Lian, RH ;
Kumar, V .
SEMINARS IN IMMUNOLOGY, 2002, 14 (06) :453-460
[85]   IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation [J].
Lodolce, JP ;
Boone, DL ;
Chai, S ;
Swain, RE ;
Dassopoulos, T ;
Trettin, S ;
Ma, A .
IMMUNITY, 1998, 9 (05) :669-676
[86]   Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells [J].
Lohoff, M ;
Duncan, GS ;
Ferrick, D ;
Mittrücker, HW ;
Bischof, S ;
Prechtl, S ;
Röllinghoff, M ;
Schmitt, E ;
Pahl, A ;
Mak, TW .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (03) :325-335
[87]   The genomic organization of the mouse CD94 C-type lectin gene [J].
Lohwasser, S ;
Wilhelm, B ;
Mager, DL ;
Takei, F .
EUROPEAN JOURNAL OF IMMUNOGENETICS, 2000, 27 (03) :149-151
[88]   Regulation of immune responses through inhibitory receptors [J].
Long, EO .
ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :875-904
[89]   Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells [J].
Loza, MJ ;
Zamai, L ;
Azzoni, L ;
Rosati, E ;
Perussia, B .
BLOOD, 2002, 99 (04) :1273-1281
[90]  
Loza MJ, 2002, EUR J IMMUNOL, V32, P413, DOI 10.1002/1521-4141(200202)32:2<413::AID-IMMU413>3.0.CO