Characterization of digital waveforms using thermodynamic analogs: Detection of contrast-targeted tissue in vivo

被引：42

作者：

Hughes, Michael S. ^{[1
]}

Marsh, Jon N. ^{[1
]}

Zhang, Hyuing ^{[1
]}

Woodson, Adam K. ^{[1
]}

Allen, John S. ^{[1
]}

Lacy, Elizabeth K. ^{[1
]}

Lanza, Gregory M. ^{[1
]}

Wickline, Samuel A. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

来源：

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL | 2006年 / 53卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1109/TUFFC.2006.1678189

中图分类号：

O42 [声学];

学科分类号：

070206 [声学]; 082403 [水声工程];

摘要：

We describe characterization of backscatter from tumor tissue targeted with a nanoparticle-based ultrasound contrast agent in vivo using analogs of thermodynamic quantities. We apply these waveform characteristics to detection of tumor neovasculature in tumors implanted in athymic nude mice, which were imaged using a research ultrasound scanner over a 2-hour period after injection of alpha(nu)beta(3)-targeted perfluorocarbon nanoparticles. Images were constructed from backscattered ultrasound using two different approaches: fundamental B-mode imaging and a signal receiver based on a thermodynamic analog (H-C). The study shows that the thermodynamic analog is capable of detecting differences in backscattered signals that are not apparent with the B-mode approach.

引用

页码：1609 / 1616

页数：8

共 21 条

[1]

Time evolution of enhanced ultrasonic reflection using a fibrin-targeted nanoparticulate contrast agent [J].