Bionanomechanical systems

被引:39
作者
Schmidt, JJ [1 ]
Montemagno, CD [1 ]
机构
[1] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
关键词
hybrid devices; molecular motors; motor proteins; nanotechnology; force transduction;
D O I
10.1146/annurev.matsci.34.040203.115827
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Over the past two decades, advances in biophysical instrumentation have enabled the study of molecular motors at the single molecule level. These studies have inspired the creation of biological/inorganic systems powered by such motors in an attempt to exploit their unique sizes, speeds, functions, and energy utilization capabilities. We give a brief overview of the state-of-the-art of biological and synthetic molecular motors and discuss some initial efforts to exploit their function in engineered structures. We also briefly discuss the construction of devices powered by organized and coordinated arrays of millions of motors in which the growth of cardiac muscle tissue over a microfabricated silicon "skeleton" is directed and controlled.
引用
收藏
页码:315 / 337
页数:25
相关论文
共 100 条
[81]   Structure of a T7 RNA polymerase elongation complex at 2.9Å resolution [J].
Tahirov, TH ;
Temiakov, D ;
Anikin, M ;
Patlan, V ;
McAllister, WT ;
Vassylyev, DG ;
Yokoyama, S .
NATURE, 2002, 420 (6911) :43-50
[82]   The motor domain determines the large step of myosin-V [J].
Tanaka, H ;
Homma, K ;
Iwane, AH ;
Katayama, E ;
Ikebe, R ;
Saito, J ;
Yanagida, T ;
Ikebe, M .
NATURE, 2002, 415 (6868) :192-195
[83]   A force transducer for measuring mechanical properties of single cardiac myocytes [J].
Tasche, C ;
Meyhöfer, E ;
Brenner, B .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (06) :H2400-H2408
[84]   Controlling kinesin by reversible disulfide cross-linking: Identifying the motility-producing conformational change [J].
Tomishige, M ;
Vale, RD .
JOURNAL OF CELL BIOLOGY, 2000, 151 (05) :1081-1092
[85]   Large conformational changes of the ε subunit in the bacterial F1F0 ATP synthase provide a ratchet action to regulate this rotary motor enzyme [J].
Tsunoda, SP ;
Rodgers, AJW ;
Aggeler, R ;
Wilce, MCJ ;
Yoshida, M ;
Capaldi, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6560-6564
[86]   Rotation of the c subunit oligomer in fully functional F1Fo ATP synthase [J].
Tsunoda, SP ;
Aggeler, R ;
Yoshida, M ;
Capaldi, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :898-902
[87]   Selective adhesion of functional microtubules to patterned silane surfaces [J].
Turner, DC ;
Chang, CY ;
Fang, K ;
Brandow, SL ;
Murphy, DB .
BIOPHYSICAL JOURNAL, 1995, 69 (06) :2782-2789
[88]   The way things move: Looking under the hood of molecular motor proteins [J].
Vale, RD ;
Milligan, RA .
SCIENCE, 2000, 288 (5463) :88-95
[89]   The design plan of kinesin motors [J].
Vale, RD ;
Fletterick, RJ .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :745-777
[90]   Force production in mechanically isolated cardiac myocytes from human ventricular muscle tissue [J].
van der Velden, J ;
Klein, LJ ;
van der Bijl, M ;
Huybregts, MAJM ;
Stooker, W ;
Witkop, J ;
Eijsman, L ;
Visser, CA ;
Visser, FC ;
Stienen, GJM .
CARDIOVASCULAR RESEARCH, 1998, 38 (02) :414-423