Gold-catalyzed cyclization of O-propargyl carbamates under mild conditions:: A convenient access to 4-alkylidene-2-oxazolidinones

被引：61

作者：

Ritter, Stefanie ^{[1
]}

Horino, Yoshikazu ^{[1
]}

Lex, Johann ^{[1
]}

Schmalz, Hans-Guenther ^{[1
]}

机构：

[1] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany

来源：

SYNLETT | 2006年 / 19期

关键词：

oxazolidinones; heterocycles; gold catalysis; alkynes;

D O I：

10.1055/s-2006-951555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On treatment with catalytic amounts of goldi(I) chloride (AuCl) and a base co-catalyst, O-propargyl carbarnates smoothly undergo a 5-exo-dig cyclization at room temperature to afford 4-methyl ene-2-oxazolidinones in high yield. Substrates with a substituent at the alkyne terminus stereoselectively give rise to (Z)-4-alkylidene-2-oxazolidinones.

引用

页码：3309 / 3313

页数：5

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