The production of fine chemicals by biotransformations

被引：526

作者：

Straathof, AJJ ^{[1
]}

Panke, S

Schmid, A

机构：

[1] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Biotechnol, CH-8093 Zurich, Switzerland

[2] Delft Univ Technol, Kluyver Lab Biotechnol, NL-2628 BC Delft, Netherlands

[3] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Proc Engn, CH-8092 Zurich, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(02)00360-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Today, biocatalysis is a standard technology for the production of chemicals. An analysis of 134 industrial biotransformations reveals that hydrolases (44%) and redox biocatalysts (30%) are the most prominent categories. Most products are chiral (89%) and are used as fine chemicals. In the chemical industry, successful product developments involve on average a yield of 78%, a volumetric productivity of 15.5 g/(L.h) and a final product concentration of 108 g/L. By contrast, the pharmaceutical industry focuses on time-to-market. The implications of this for future research and development on biocatalysis are discussed.

引用

页码：548 / 556

页数：9

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