Lead development: Validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors

被引：11

作者：

Singh, J

Soloweij, J

Allen, M

Killar, L

Ator, M

机构：

[1] STERLING WINTHROP RES INST,DIV PHARMACEUT RES,DEPT MED CHEM,COLLEGEVILLE,PA 19426

[2] STERLING WINTHROP RES INST,DIV PHARMACEUT RES,DEPT ENZYME & RECEPTOR BIOCHEM,COLLEGEVILLE,PA 19426

[3] STERLING WINTHROP RES INST,DIV PHARMACEUT RES,DEPT PHARMACOL,COLLEGEVILLE,PA 19426

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 05期

关键词：

D O I：

10.1016/0968-0896(96)00057-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An approach utilizing robotics (automation) for the rapid and reliable determination of protease inhibitor concentration in rat plasma samples is described. The bioassay protocol using an immobilized peptide substrate allows high sample throughput, compatible with parallel synthesis/SAR development strategy. Copyright (C) 1996 Elsevier Science Ltd.

引用

收藏

页码：639 / 643

页数：5

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