Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?

被引：225

作者：

Harel, Noam Y.

Strittmatter, Stephen M.

机构：

[1] Yale Univ, Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, Dept Neurol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, Dept Neurobiol, New Haven, CT 06520 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 08期

关键词：

D O I：

10.1038/nrn1957

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The precise wiring of the adult mammalian CNS originates during a period of stunning growth, guidance and plasticity that occurs during and shortly after development. When injured in adults, this intricate system fails to regenerate. Even when the obstacles to regeneration are cleared, growing adult CNS fibres usually remain misdirected and fail to reform functional connections. Here, we attempt to fill an important niche related to the topics of nervous system development and regeneration. We specifically contrast the difficulties faced by growing fibres within the adult context to the precise circuit-forming capabilities of developing fibres. In addition to focusing on methods to stimulate growth in the adult, we also expand on approaches to recapitulate development itself.

引用

页码：603 / 616

页数：14

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