Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula

被引:46
作者
Luesch, H
Yoshida, WY
Moore, RE [1 ]
Paul, VJ
机构
[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA
[2] Univ Guam, Marine Lab, UOG Stn, Mangilao, GU 96923 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 12期
关键词
D O I
10.1021/np990310z
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Lyngbyastatin 2 (1) and norlyngbyastatin 2 (2), new cytotoxic analogues of dolastatin G (3) and nordolastatin G (4), respectively, have been isolated as constituents from a Guamanian variety of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of these cyclic depsipeptides relied on extensive application of 2D NMR techniques. The finding of these new metabolites further supports the proposal that many compounds originally isolated from the sea hare Dolabella auricularia are most likely of cyanobacterial origin.
引用
收藏
页码:1702 / 1706
页数:5
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